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PURPOSE To derive the value of corneal epithelial barrier to fluorescein in humans from experiments in which the fluorophore in instilled in a single drop. METHOD A commercial scanning fluorophotometer, the Fluorotron Master, was used to scan through an anterior segment. It could not resolve the tear film from the cornea, but in the early stages of(More)
The pathways by which fluorescein (F), fluorescein glucuronide (FG) and fluorescein dextran (FD) leave the vitreous body of the rabbit were examined by measuring the concentration distribution of the injected fluorophores in sections of the frozen eyes. The contours of F, as already known, show that it leaves the vitreous predominantly across the retinal(More)
Small, experimental, non-rhegmatogenous retinal detachments (blebs) in rabbit eyes resorbed 50% more slowly when filled with autologous serum than with Hanks' solution. To study the fate of large molecules in the subretinal space, carboxyfluorescein and several sizes of FITC-dextrans were injected into blebs and their movement followed by fluorophotometry.(More)
A technique of recording from single units of the isolated rat cornea is described. The corneal surface is stimulated by a jet of fluid, which allows continuously graded pressure and thermal or chemical stimuli to be applied at the same point. Some units respond to stimulation anywhere in a field of about one-third the corneal area, and others only to point(More)
This paper addresses the practical problems raised by the fact that correlation integrals computed from electroencephalographic signals do not scale. An automated procedure is described for alpha-waves, which is based on the known method of determining the correlation dimension from scaled structures that appear in diagrams of slope-curves. Automation,(More)
When fluoresceinated dextran (FD) is injected into the vitreous body of the rabbit, it diffuses out of the eye through the anterior chamber so that the ratio of its concentration in the aqueous to that in the vitreous humor remains constant. The rate of loss of the substance from the eye suggests that the vitreous body is stagnant. After penetrating the(More)
Fluoresceinated IgG was injected centrally into the rabbit's cornea and both its rate of loss from the tissue and its rate of spread in the stroma were estimated by objective fluorometry. A new technique for determining the rate of loss was established which required only the measurement of the maximum fluorescence in the tissue. The rate at which freshly(More)