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1. The rate of diffusion of [(14)C] sucrose through rat diaphragm muscle is dependent on the period of preliminary soaking of the muscle in Krebs solution at 36 degrees C. The ratio of the length of the diffusion path through the diaphragm to its geometrical thickness appears to fall from 4.39+/-0.38 (S.E. of the mean) to 2.23+/-0.18 after about 6 h of(More)
Differences in the relative potencies of agonists have been used successfully in the past to classify receptors. Such use of agonists can be justified on the basis of ideas and equations developed using the occupancy model of drug action. However the occupancy model makes no allowance for possible complications which may arise when the drug-receptor complex(More)
  • D. Mackay
  • Trends in pharmacological sciences
  • 1990
The relative potencies of agonists have been used in the past to classify receptors. This could be justified on the basis of ideas and equations developed using the occupancy model of drug action. Although attempts have been made recently to develop methods of analysis based on other models, these have not been entirely satisfactory. In this article Dennis(More)
Microbial communities in subsurface environments are poorly characterized and the impacts of anthropogenic contamination on their structure and function have not been adequately addressed. The release of contaminant(s) to a previously unexposed environment is often hypothesized to decrease the diversity of the affected community. We characterized the(More)