D. M. Zubairov

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The dynamics of microvesicle formation in arterial blood in generalized Schwartzman phenomenon was studied. Successive (with 24-h interval) intravenous injections of endotoxin to rabbits in a dose of 1 mg/kg and 3 mg/kg caused an increase in the content of microvesicles in the blood, some of them containing ecto-5′-nucleotidase. Biphasic changes in arterial(More)
The effect of the product of the contact phase of blood clotting (CAP), i.e., factor XII and its activated form on the reaction of reduction of nitro-BT by human neutrophils was studied. In all cases CAP caused marked stimulation of the neutrophils. The response of the neutrophils to factor XII was observed irregularly. It was more regular and stronger(More)
The work is devoted to the analysis of hemocoagulation and fibrinolytic properties of a commercial preparation of alkaline phosphatase from the mucosa of the small intestine of a chick. The results of this work indicated that the catalytic separation of the phosphate groups under the effect of alkaline phosphatase was not a significant link in the(More)
An attempt to study direct hormonal regulation of the blood coagulating system by catecholamines, using the affinity chromatography method, was made. It was found that human blood plasma is adsorbed and the enzyme hydrolyzing N-benzoyl-L-arginine, is activated on the column. It was found that human blood plasma after the contact with norepinephrine loses(More)
Fibronectin, a high-molecular-weight glycoprotein circulating in blood and other biological fluids, is known as an opsonin with a broad spectrum of action [2, 6]. Receptors for fibronectin have been on the cell surface of peripheral blood macrophages [4, 5] and alveolar macrophages [3]. It has been suggested that fibronectin can play the role of opsonin for(More)
Adrenaline administration (0.5 mg/kg) in rabbits shortened the blood clotting time for about 30 min, whereas under the lysozyme effect no shortening occurred. I. v. lysozyme administration (0.05 mg/kg) induced clear though transitory decrease of total and latent BAEE-esterase activity of the blood plasma. The data obtained emphasize the role of factor XII(More)
Intravenous injection of 1 µg/kg desmopressin to rabbits not only accelerated clotting of arterial blood (maximally by 59.16±8.53% after 1 h), but also increased the number of microvesicles containing the integral enzyme 5′-nucleotidase in the arterial blood from the initial level of 36.26±8.08 ncat/liter to a maximum of 99.65±15.8 ncat/liter after 15 min.
Exo- and endolectins affined to N-acetylgalactosamine, N-acetylglucosamine, galactose, mannose and fucose, added in vitro to suspension of tissue thromboplastin from human brain, suppress its blood coagulation activity by 50-88% (p less than 0.05). This result has been considered as an argument for the advantage of the opinion that the specific blood(More)