Learn More
Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominant-negative mutant of HDAC1 or downregulation of HDAC1 by(More)
A model for Raman scattering by a molecule adsorbed at the surface of a spherical particle is articulated by treating the molecule as a classical electric dipole. This follows Moskovits's suggestion [J. Chem. Phys. 69, 4159 (1978)] and the experiments by Creighton et al. [J. Chem. Soc. Faraday Trans. II, 75, 790 (1979)] that such a system may exhibit SERS(More)
The extended boundary condition method is used to make angular scattering calculations for a polydisperse suspension of prolate spheroidal particles. To aid in interpretation of the nonspherical results, calculations are also made for spherical particle suspensions. The basic particle models are two-layered approximations of common bacteria. Using a(More)
The extended boundary condition method is applied to 3-D electromagnetic scattering problems involving multilayered dielectric objects. The theoretical formulation is reviewed, and the numerical problems are discussed. Angular scattering calculations have been made for bacteria-like layered prolate spheroids with a nucleus-like inner layer and a(More)
Rayleigh-Gans-Debye scattering theory is applicable to particles satisfying |m - 1| << 1 and 2ka |m - 1| << 1. It is often applied to large nonspherical particles such as bacteria where its validity is uncertain. The purpose of this study is to define the range of validity of the RGD approximation as applied to homogeneous nonspherical particles. Scattering(More)
Measurements and theoretical calculations of fluorescent emission from four samples of polystyrene microspheres (diameter 0.92, 1.63, 1.90 and 4.18 microns) containing the same fluorescent dye show a general dependence upon particle size, emission angle, and polarization conditions. However, for the excitation and detection conditions used in flow(More)
A model for Raman scattering by a molecule adsorbed at the surface of a spherical particle is articulated by treating the molecule as a classical electric dipole. This follows Moskovits's suggestion [J. Chem. Phys. 69, 4159 (1978)] and the experiments by Creighton et al. [J. Chem. Soc. Faraday Trans. II, 75, 790 (1979)] that such a system may exhibit SERS(More)
The defibrinogenating effect of batroxobin (Defibrase) in male Wistar rats and the inhibitory effects of the plasma of batroxobin-treated rats on the migration of human vascular smooth muscle cells (SMCs) were investigated in vitro. At 1 h after a single intravenous injection of 3.0, 10.0 or 30.0 BU/kg batroxobin (ten rats in each group), the fibrinogen(More)