D. M. Ryan

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Baclofen (Lioresal) is a derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is used to treat spasticity particularly for the relief of flexor spasms, pain, clonus, and muscular rigidity. There have been many rare neurologic side effects reported with its use. These side effects, in particular, hallucinations and seizures, have(More)
Nickel-Titanium (NiTi) peripheral stents are commonly used for the treatment of diseased femoropopliteal arteries (FPA). However, cyclic deformations of the vessel, induced by limb movements affect device performance and fatigue failure may occur. Stent strut fracture has been described in the literature, and is implicated as a potential causative factor in(More)
These notes are based on a course of lectures given at Stanford, and cover three major topics relevant to optimization theory. First an introduction is given to those results in mathematical programming which appear to be most important for the development and analysis of practical algorithms. Next unconstrained optimization problems are considered. The(More)
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