D. M. Kadyrova

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Some of the hydrochlorides of the s tereoisomeric benzoic es ters of 1-R-2-methyldecahydroquinoline-4ol(R =H, alkyl, alkenyl) have been reported to be physiologically active and to have been used as anesthetics of different types; a relationship has been established between the pharmacological activity of the compound and the s ter ic s t ructure of the(More)
Three series of amidoxime derivatives including nitrous derivatives of α-chloro-α-isonitrosoacetone and hydrochlorides of O-aroyl-β-aminopropioamidoximes and 3-[β-(piperidin-1-yl)]ethyl-5-aryl-1,2,4-oxadiazoles were tested for conduction, infiltration, and terminal anesthesia. There are four interesting “hit” compounds, i.e., the hydrochloride of(More)
Compounds with high anesthetizing activity have been detected among oxygen derivatives of decahydroquinoline [8]. ~ A number of stereoisomerlc benzoic acid esters of l-R-2-methyl-decahydroquinollne-4-ol (R = CI-C 5 alkyl, allyl, etc. ) have clearly expressed local-anesthetic activity [i0]. However, they, like the anesthetics being used in practice, do not(More)
Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54,(More)
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