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BACKGROUND AND PURPOSE Brain arteriovenous malformations (AVMs) occur in approximately 0.14% of the population. The most common presentations are hemorrhage (50%) and seizures (25%). Although they are congenital abnormalities, their angioarchitecture may vary over time. A rare but well-recognized phenomenon of AVMs is that of spontaneous obliteration. It is(More)
Eighteen patients with cerebral cavernous malformations were treated with single dose of cobalt 60 source stereotactic radiosurgery. All had suffered at least one haemorrhage prior to treatment with six suffering 2, four suffering 3 and one suffering 4. Mean follow-up was 4.5 years. A total of 36 pretreatment haemorrhages occurred in 139 patient years. The(More)
This phantom study assesses the accuracy of stereotactic localization using the Leksell G frame (Elekta Instruments AB, Stockholm, Sweden) with T1-weighted magnetic resonance imaging (Siemens 1.5 T Magnetom; Erlangen, Germany). The coordinates of an array of solid perspex rods were determined and compared with measured values in a series of transverse,(More)
The stereotactic radiosurgery unit in Sheffield became operational in September 1985 and over 180 patients harbouring AVMs have been treated. The first 52 patients underwent one year follow up angiography and comprise the material for this study. At one year 26 patients (50%) already had a favourable outcome (16 complete and 10 almost complete(More)
Four-vessel angiography was repeated in 56 patients with confirmed subarachnoid hemorrhage in whom the initial investigation was negative. Only one aneurysm was demonstrated. The results suggested that, with good technique, careful observation, and a complete four-vessel cerebral angiography, a false negative rate of less than 2% can be achieved. It is(More)
OBJECTIVE To compare the accuracy of stereotactic localization using magnetic resonance imaging (Siemens 1.5-T Magnetom; Siemens, Erlangen, Germany) with two-dimensional and three-dimensional data acquisition techniques. METHODS A phantom study was performed in which the coordinates of an array of rods were determined from images in both two-dimensional(More)
OBJECTIVES To examine the structural changes in arteriovenous malformations (AVMs) after stereotactic radiosurgery and to identify the cytoskeletal antigen phenotype of the proliferating cells to gain information about the possible mechanism of obliteration. METHODS We conducted immunohistochemical and electromicroscopic investigations of surgical(More)
A retrospective multicenter study was performed to evaluate the effectiveness of Gamma Knife radiosurgery (GKRS) in the treatment of drug resistant epilepsy associated with cavernous hemangiomas (CH). The mean duration of epilepsy before GKRS was 7.5 ¿ 9.3 years. The mean frequency of seizures was 6.9 ¿ 14/month. The mean marginal dose was 19.2 ¿ 4.4 Gy(More)
The relationship between clinical condition and vasoconstrictor factors in cerebrospinal fluid was studied in 19 patients for up to six weeks after subarachnoid haemorrhage. Vasoconstrictor activity was assayed biologically. Sixteen of 19 patients improved as vasoconstrictor activity declined; this pattern was not significantly influenced by surgery. Serial(More)