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Breast cancer stem cells (BCSCs) are the source of breast tumors. Compared with other cancer cells, cancer stem cells show high resistance to both chemotherapy and radiotherapy. Targeting of BCSCs is thus a potentially promising and effective strategy for breast cancer treatment. Differentiation therapy represents one type of cancer stem-cell-targeting(More)
  • D. Le
  • 1985
An algorithm is presented for finding a root of a real function. The algorithm combines bisection with second and third order methods using derivatives estimated from objective function values. Globaql convergence is ensured and the number of function evaluations is bounded by four times the number needed by bisection. Numerical comparisons with existing(More)
Vascular endothelial growth factor (VEGF) is involved in the growth of new blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in mitosis involving in cell proliferation. Simultaneous silencing of VEGF and KSP, an attractive and viable approach in cancer, leads on restricting cancer progression. The purpose of this study(More)
An electrical and physical design power optimization methodology and design techniques developed to create an ARM 1136SF-S microprocessor in 9Onm standard CMOS are presented. A 40% reduction in power dissipation has been achieved while maintaining a 355 MHz operating clock rate under typical conditions. Functional and electrical design requirements were(More)
A system-centric, fully-hierarchical design methodology and design techniques developed to create four ICs, which provide the core functionality of a multi-Gigabit switching network system, are presented. The system is capable of switching more than 500 million packets per second. Electrical and physical design methods for one IC are described. /spl sim/76(More)
Skin aging is the result of internal and external factors. So-called photoaging has been identified as the major factor in skin aging. Effects of photoaging include inhibition of fibroblast and keratinocyte proliferation as well as collagen and fibronectin expression, while activating expression of collagenases such as matrix metalloproteinase-1. Previous(More)