D. Laroche

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Kappa(kappa) opioid agonists slow gastrointestinal transit in the guinea pig and the mouse but not the rat. Opioid antagonists naloxone and naltrexone are mu (mu) preferring, while the antagonist nalmefene has more kappa binding activity. When administered orally, the specific opioid antagonists naloxone, naltrexone, and nalmefene are able to reverse the(More)
Motor imagery is the ability to mentally simulate a movement without executing it. Previous investigations have reported a deterioration of this ability during complex arm movements in aged adults. In the present study, we aimed to extend these findings by investigating the temporal features of imagined precision gait in healthy elderly adults. Locomotion(More)
Rheumatoid arthritis (RA) is a leading cause of disability, which affects primarily the forefoot. Moreover, the forefoot is the final ground body interface for transmitting forces produced by the plantar flexors in order to move the body forward. Therefore, a dysfunction in patients with arthritis might induce important changes in gait, such as(More)
OBJECTIVES Kinematic gait analysis consisting of measuring gait parameters (stride length, gait speed, dynamic joint angles) is a potential outcome measure in osteoarthritis (OA). The aim of this study was to evaluate its psychometric properties. METHODS A systematic literature search was performed in PUBMED and the Cochrane database until January 2008 by(More)
OBJECTIVES (1) to investigate the test-retest reliability of 3D gait analysis (3DGA) in hip Osteoarthritis (OA) patients; (2) to find the minimum number of gait trials needed to overcome intrinsic variability; (3) to check the accuracy of angles measured by the 3D system. DESIGN 23 Patients suffering from hip OA with no other major disease were recruited.(More)
OBJECTIVE To describe the kinematic adaptations of all lower limb joints in hip osteoarthritis patients during walking. METHODS Patients with unilateral primary hip OA, without associated joint disorders were included. Normal subjects were included as controls. Gait analysis, using a 3-dimensional computerised gait analysis system was used to evaluate the(More)
Although the rat has become the favourite animal model in preclinical research on locomotion, studies designed to assess the strategy used by rats to avoid obstacle are lacking. Using an optoelectronic 3D motion analysis system, we therefore, compared the step pattern, timing and length variables of locomotor cycles, trajectories and joint angles of limbs(More)
It is well known that center of pressure (CoP) displacement correlates negatively with the maximal isometric torque (MIT) of ankle muscles. This relationship has never been investigated in elderly fallers (EF). The purpose of this study was thus to analyze the relationship between the MIT of ankle muscles and CoP displacement in upright stance in a sample(More)
The main aim of our study was to investigate the possibility of applying machine learning techniques to the analysis of electromyographic patterns (EMG) collected from arthritic patients during gait. The EMG recordings were collected from the lower limbs of patients with arthritis and compared with those of healthy subjects (CO) with no musculoskeletal(More)
BACKGROUND Although the striatum is in position to regulate motor function, the role of the structure in locomotor behaviour is poorly understood. Therefore, a detailed analysis of locomotion- and obstacle avoidance-related parameters was performed after unilateral lesion of the striatum in rats. METHODS AND RESULTS Using the three dimensional motion(More)