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Blood serum is a complex body fluid that contains various proteins ranging in concentration over at least 9 orders of magnitude. Using a combination of mass spectrometry technologies with improvements in sample preparation, we have performed a proteomic analysis with submilliliter quantities of serum and increased the measurable concentration range for(More)
Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation. An emerging body of evidence links platelet function and thrombosis to vascular inflammation. peroxisome proliferator-activated receptors (PPARs)(More)
BACKGROUND Interventions to support people with hypertension in attending clinics and taking their medication have potential to improve outcomes, but delivery on a wide scale and at low cost is challenging. Some trials evaluating clinical interventions using short message service (SMS) text-messaging systems have shown important outcomes, although evidence(More)
In the past few decades heart sound signals (i.e., phono-cardiograms or PCGs) have been widely studied. Automated heart sound segmentation and classification techniques have the potential to screen for pathologies in a variety of clinical applications. However, comparative analyses of algorithms in the literature have been hindered by the lack of a large(More)
NOTICE This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, subcontractors, or affiliated partners makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness,(More)
Improvements to wall systems, window systems, and insulation installation standards have been encouraged by state building standards, ENERGY STAR®, and other programs over the past decade, resulting in significant strides in new home building performance. These improvements in above grade envelope performance have resulted in slab edge perimeter losses(More)
To determine how the repertoire of plasma membrane proteins change with disease state, specifically related to cancer, several methods for preparation of plasma membrane proteins were evaluated. Cultured cells derived from stage IV ovarian tumors were grown to 90% confluence and harvested in buffer containing CHAPS detergent. This preparation was(More)
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