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Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum, there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7--these chromosomes account for approximately 55% of the total genome. We describe(More)
Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it(More)
Normal mice and mice with septal lesions were trained on a differential-reinforcement-for-low-rates-of-responding (DRL 8-sec) schedule for the reinforcement varying in incentive value. Dilution of diet increased the number of reinforcements received by mice with septal lesions. In Experiments 2 and 3 the effects of septal lesions on resistance to extinction(More)
Intraventricular administration of ACTH1-24 into the rat induced excessive grooming behavior. This response could be blocked by local administration of of neuroleptics into either the nucleus accumbens or the neostriatum. Local administration of [Des-Tyr1]-gamma-endorphine (LPH62-77) but not alpha-endorphin (LPH61-76) in either the nucleus accumbens or the(More)
Dopamine (DA) was injected unilaterally into the dorsal caudate-putamen (D-CPU), ventral caudate-putamen (V-CPU), piriform cortex (PIR), olfactory tubercle (OTU) and frontal cortex (FC) of two day old rats and rotational behavior observed. Injection of DA into D-CPU, PIR, and OTU produced a contralateral postural deviation which differed significantly from(More)
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