D.L Mallery

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Antibodies can be carried into the cell during pathogen infection where they are detected by the ubiquitously expressed cytosolic antibody receptor TRIM21. Here we show that TRIM21 recognition of intracellular antibodies activates immune signaling. TRIM21 catalyses K63ubiquitin chain formation, stimulating transcription factor pathways NF-κB, AP-1 and IRF3,(More)
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