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The effect of vidarabine, a new antiviral agent, on the offspring of rats, rabbits, and monkeys was studied by varying routes of administration during several periods of gestation. Vidarabine demonstrated a dose-related teratogenic effect in rats when given parenterally at doses of 30 mg/kg and greater. The drug was also teratogenic in the rabbit at dosages(More)
Rat offspring malformed as a result of maternal exposure to a teratogen were cannibalized preferentially to apparently normal offspring. Lack of viability also appeared to be a factor in the cannibalistic tendency, since both normal and malformed dead pups were consumed more frequently than viable pups of either category. Of the 29 cannibalized pups(More)
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