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The orexin system is a key regulator of sleep and wakefulness. In a multicenter, double-blind, randomized, placebo-controlled, two-way crossover study, 161 primary insomnia patients received either the dual orexin receptor antagonist almorexant, at 400, 200, 100, or 50 mg in consecutive stages, or placebo on treatment nights at 1-week intervals. The primary(More)
Interrater variability of sleep stage scorings is a well-known phenomenon. The SIESTA project offered the opportunity to analyse interrater reliability (IRR) between experienced scorers from eight European sleep laboratories within a large sample of patients with different (sleep) disorders: depression, general anxiety disorder with and without non-organic(More)
In lumbar fusion, controversy remains regarding the effectiveness of cross-linking and the necessity of placing pedicle screws at the intermediate levels of the segment to be fused. The purpose of this study is to evaluate the stiffness of various rod/screw constructs used to instrument a three-level fusion with specific emphasis on the effect of(More)
A system is described that allows axial, torsional, and bending testing of biomechanical specimens. The system uses electric motors under closed loop control in its grips allowing application of pure bending moments. These grips attach to an axial/torsional testing system. Thus, it provides simultaneous closed loop control of all three degrees of freedom(More)
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