D. Koyama

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The Notch signaling pathway has been recognized as a key factor for the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), because of the high incidence of activating mutations of Notch1. Notch inhibition could serve as a new treatment strategy for T-ALL; however, the attempts to perturb Notch signaling pathways have been unsuccessful so far. In(More)
Histone modifications have crucial roles in diverse biological processes including development, differentiation and oncogenesis. Among them, acetylation of histone H3 at the lysine-18 residue (H3K18) is particularly important, because specific deacetylation of H3K18 is indispensable for oncogenic transformation by adeno-virus 1 and for host responses to(More)
Multiple-choice formats remain a popular design for assessing listening comprehension, yet no consensus has been reached on how multiple-choice formats should be employed. Some researchers argue that test takers must be provided with a preview of the items prior to the input (Buck, 1995; Sherman, 1997); others argue that a preview may decrease the(More)
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