D. K. Sehgal

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Pneumonia leads to high mortality in children under the age of five years worldwide, resulting in close to 20 percent of all deaths in this age group. Therefore, investigations into host-pathogen interactions during Streptococcus pneumoniae infection are key in devising strategies towards the development of better vaccines and drugs. To that end, in this(More)
Streptococcus pneumoniae is a leading cause of bacterial pneumonia, sepsis and meningitis. Surface accessible proteins of S. pneumoniae are being explored for the development of a protein-based vaccine in order to overcome the limitations of existing polysaccharide-based pneumococcal vaccines. To identify a potential vaccine candidate, we resolved(More)
Purpose. To analyze the stress distribution in an endodontically treated maxillary central incisor restored with various post-core systems and assess the benefit of ferrule using finite element analysis. Material and Methods. Twelve models with metal ceramic crown were created based on the combination of three types of post-core systems (titanium(More)
The Lef1 transcription factor expression defines airway progenitor cell targets for in utero gene therapy of submucosal gland in cystic fibrosis. Polarity Influences the efficiency of recombinant adeno-associated virus infection in differentiated airway epithelia. Two independent molecular pathways for rAAV genome conversion occur following UV-C and E4orf6(More)
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