D. K. Huang

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AIM To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of metoprolol stereoisomers, and compare their inhibitory effects on cardiovascular system in the spontaneously hypertensive rats (SHR). METHODS The drug concentration in plasma was measured by the reversed phase HPLC and the drug effects were recorded by polygraph. The(More)
The saponins (ASI, SK) used in this study was extracted from the root of Astragalus membranaceous Bge and Astragalus sieversianus Pull. ASI and SK were found to protect liver from chemical injury induced by CCl4, D-galactosamine and acetaminophen in mice. The two saponins were shown to impede the elevation of SGPT level, decrease the MDA content and(More)
Although the central mechanisms of electroacupuncture analgesia (EAA) have been investigated, a systematic study for the involvement of neuronal populations of central nervous system (CNS) in EAA has not been well undertaken, largely due to the difficulty in tracing the neuronal pathways by traditional techniques. Recently developed c-fos expression(More)
This study applied immunohistochemistry method to examine the pattern of c-fos expression in the neuraxis following peripheral noxious thermal stimulation accomplished by immersion of tail of awake rat into hot water (50 degrees C). In unstimulated control rats, no obvious baseline expression of c-fos protein was found except in nucleus paraventricularis(More)
This study had the objective to understand the central effect of electro-acupuncture analgesia (EAA) on visceral pain of rats. We used the method of Sokoloff's 2-deoxyglucose (2-DG) auto-radiographic quantitative analysis to observe the changes of local cerebral metabolic rate of glucose (LCMRG) in rats given electrical stimulation of greater splanchnic(More)
AIM To compare the densities of opioid receptors in spontaneously hypertensive rats (SHR) with those of normotensive Wistar-Kyoto (WKY) rats in central nervous system which are related to the regulation of BP. METHODS [3H] Etorphine, a nonspecific opioid ligand, was used to determine the distributions of opioid receptors in 16-wk-old SHR and WKY rats by(More)
Radioreceptor-binding assay combined with autoradiography technique in the brain slices of rats was used to investigate cerebral areas related to electroconvulsive shock (ECS) and to analyze changes of opioid receptors of these areas in electroacupuncture (EA) anticonvulsion. The results from image processing and detection of optic density (O.D.) showed(More)
AIM To compare the pharmacokinetics of domestic and imported sustained-release capsule of 5-isosorbide mononitrate (5-IM). METHODS A single and 5-d-repeated oral doses of 5-IM 50 mg were performed on 2 groups of 20 Chinese healthy subjects (10 subjects for each group) in a randomized crossover protocol. The 5-IM in plasma were measured by gas(More)
The formaldehyde histofluorescence method and receptor autoradiography were respectively used to investigate the distribution and densities of the catecholamine (CA) terminals and [3H]-etorphine binding sites, after 20 days of injection of 6-hydroxydopamine (6-OHDA) into N. subcoerulens of the rabbit. The results showed that both CA terminals and(More)