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Increased myocardial lipid content (MYCL) recently has been linked to the development of cardiomyopathy in diabetes. In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resistance. Thus, we hypothesized that cardiac steatosis might develop against the background of the metabolic(More)
AIMS/HYPOTHESIS Recent evidence suggests a link between myocardial steatosis and diabetic cardiomyopathy. Insulin, as a lipogenic and growth-promoting hormone, might stimulate intramyocardial lipid (MYCL) deposition and hypertrophy. Therefore, the aim of the present study was to investigate the short-term effects of insulin therapy (IT) on myocardial lipid(More)
BACKGROUND Obesity is a major risk factor to develop heart failure, in part due to possible lipotoxic effects of increased intramyocardial (MYCL) and/or local or paracrine effects of pericardial (PERI) lipid accumulation. Recent evidence suggests that MYCL is highly dynamic and might rather be a surrogate marker for disturbed energy metabolism than the(More)
Moisture flow in porous media is the driving force behind early age drying shrinkage. Fracture in the interfacial transition zone (ITZ), between cement paste and aggregate-inclusion, is related to restraint caused by, among others, aggregates that obstruct free deformation of the paste. Environmental Scanning Electron Microscope (ESEM) test results are used(More)
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