D. James

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Evacetrapib is a novel cholesteryl ester transfer protein (CETP) inhibitor currently being evaluated in a late-stage cardiovascular outcome trial. Using population-based models, we analyzed evacetrapib concentration data along with high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) data from a 12-week study in(More)
The aim of this study was to develop a screening system of chest radiographs of miners with pneumoconiosis. Chest radiographs were of coal mine or silica dust exposed miners participating in a health screening program. A total of 236 regions of interest (ROIs) (166, 49, and 21 with profusions of category (shape and size) 0, 1(q), and 1(r), respectively)(More)
This tutorial presents the application of an R package, RxODE, that facilitates quick, efficient simulations of ordinary differential equation models completely within R. Its application is illustrated through simulation of design decision effects on an adaptive dosing regimen. The package provides an efficient, versatile way to specify dosing scenarios and(More)
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