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Disease states such as arthritis may interact with the kinetics of β-blockers. Acebutolol (AC) is a chiral β-blocker which is available as a racemate. The beneficial properties of AC, however, is attributed mainly to theS-(+)-enantiomer. The disposition of AC enantiomers and their active, chiral metabolites, diacetolol (DC) were examined after oral(More)
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