D. J. Minchella

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The effects of drug treatment of human hosts on a population of schistosome parasites depends on a variety of factors. Previous models have shown that multiple strains of drug-resistant parasites are likely to be favored as the treatment rate increases. However, such models have neglected to account for the complex nature of schistosome mating biology. To(More)
BACKGROUND New chemotherapeutic agents against Schistosoma mansoni, an etiological agent of human schistosomiasis, are a priority due to the emerging drug resistance and the inability of current drug treatments to prevent reinfection. Proteases have been under scrutiny as targets of immunological or chemotherapeutic anti-Schistosoma agents because of their(More)
The clumping parameter related to the distribution of schistosome parasites is obtained by fitting a negative binomial distribution to data collected from patients in a village in Brazil; the natural uninfected and parasite-induced snail host mortality rates are obtained from laboratory data. These values are used in a schistosomiasis model proposed earlier(More)
The interaction between multiple parasite strains within different host types may influence the evolutionary trajectories of parasites. In this article, we formulate a deterministic model with two strains of parasites and two host types in order to investigate how heterogeneities in parasite virulence and host life-history may affect the persistence and(More)
Allelic variation in 6 microsatellite markers was compared between frozen Schistosoma mansoni eggs and laboratory-passaged worms originating from the same 5 fecal samples obtained from Brazilian residents. Based on allelic richness values, the number of alleles detected per locus did not differ between egg and worm DNA templates. However, our ability to(More)
Transposable elements (TEs) are mobile genes with an inherent ability to move within and among genomes. Theory predicts that TEs proliferate extensively during physiological stress due to the breakdown of TE repression systems. We tested this hypothesis in Schistosoma mansoni, a widespread trematode parasite that causes the human disease schistosomiasis.(More)
Parasites can profoundly impact their hosts and are responsible for a plethora of debilitating diseases. To identify global changes in host gene expression related to parasite infection, we sequenced, assembled, and annotated the liver transcriptomes of Balb/cj mice infected with the trematode parasite Schistosoma mansoni and compared the results to(More)
Parasite genetic variation has been used to delineate and enumerate species, describe host–par-asite associations, and observe the distribution of lineages among hosts and throughout the environment. Mechanisms or pathways inferred by these studies have often been carried forward in a predictive manner to inform assumptions about the organism's biology, its(More)
If you can read the text at right, you can read binary code. What you're seeing is the feature on the 50th anniversary of the computer science department that appears on page 22 translated into binary code. A binary code is a way of representing text or computer processor instructions by the use of the binary number system's two-binary digits 0 and 1. This(More)
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