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The effect of a 1 mg dose of intravenous Vitamin D3 (40,000 i.u.) on bone histology and phosphate metabolism was investigated in 19 patients with normal bone histology and 28 patients with histological evidence of osteomalacia. No significant changes occurred in the control patients after Vitamin D but the patients with osteomalacia showed a marked(More)
Many workers have shown that vitamin D deficiency induces changes in bone ultrastructure in animals. Engfeldt and Zetterstr#{246}m (1955) showed that there were abnormalities in osteoid tissue and in its calcification by applying microradiography and x-ray diffraction to the study of bone in rachitic rats. Termine and Posner (1967) showed by(More)