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Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse transcriptase inhibitors has been limited by the emergence of resistant viral variants. Similarly, variants expressing resistance to protease inhibitors have been(More)
The origins of several phenomena of number-fact retrieval were investigated by having children in Grades 3 and 4 memorize alphaplication facts (arithmetic-like memory items composed of letters instead of numbers). Alphaplication performance paralleled memory for arithmetic facts in several important respects: Results showed (a) a large performance advantage(More)
The innate genetic variability characteristic of chronic hepatitis C virus (HCV) infection makes drug resistance a concern in the clinical development of HCV inhibitors. To address this, a transient replication assay was developed to evaluate the replication fitness and the drug sensitivity of NS5B sequences isolated from the sera of patients with chronic(More)
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