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There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin avb6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the b6 integrin subunit and extracellular signal-regulated kinase 2. Targetting either(More)
Decay-accelerating factor (DAF), a widely expressed membrane complement-regulatory protein, is utilized as a cellular receptor by many human enteric pathogens. We show here that the binding of two enteroviruses to individual short consensus repeats (SCR) of DAF on the cell surface is greatly augmented by mAb binding to an alternate SCR: Coxsackievirus A21(More)
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