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This paper gives an overview of the BlueGene/L Supercomputer. This is a jointly funded research partnership between IBM and the Lawrence Livermore National Laboratory as part of the United States Department of Energy ASCI Advanced Architecture Research Program. Application performance and scaling studies have recently been initiated with partners at a(More)
In humans, mutations of amyloid precursor protein (APP) and presenilins (PS) 1 and 2 are associated with amyloid deposition, brain structural change and cognitive decline, like in Alzheimer's disease (AD). Mice expressing these proteins have illuminated neurodegenerative disease processes but, unlike in humans, quantitative imaging has been little used to(More)
We compared two methods of measuring cerebral atrophy in a cohort of 38 clinically probable Alzheimer's disease (AD) subjects and 22 age-matched normal controls, using metrics of zero atrophy, consistency, scaled atrophy and AD/control group separation. The two methods compared were the boundary shift integral (BSI) and a technique based on the integration(More)
Dynamic MRI is restricted due to the time required to obtain enough data to reconstruct the image sequence. Several undersampled reconstruction techniques have been proposed to reduce the acquisition time. In most of these techniques the nonacquired data are recovered by modeling the temporal information as varying pixel intensities represented in time or(More)
Medical research and drug discovery rely increasingly on comparisons between magnetic resonance images from large numbers of subjects, often with multiple time points for each subject. We applied image registration and visualisation techniques for quantitative and qualitative assessment of changes over time in an experimental model of rheumatoid arthritis.(More)
—The paper focuses on modelling and system identification of an air handling unit (AHU), which is part of larger heating ventilation and air conditioning (HVAC) system dedicated for clean room manufacturing. The aim is to use the model for subsequent control optimisation and further for control system design. The underlying physical relations of an AHU are(More)
Radio-frequency (RF) ablation uses electrode-catheters to destroy abnormally conducting myocardial areas that lead to potentially lethal tachyarrhythmias. The procedure is normally guided with x-rays (2D), leading to errors in location and excessive radiation exposure. One of our goals is to provide pre-and intra-operative 3D MR guidance in XMR systems(More)
The goal of an emergency health services system is to retrieve, care for and deliver the patient to appropriate medical care as soon as possible in the best conditions under the circumstances. The efficient dispatching of an ambulance is critical in matters of life and death. Like other growing cities, Ottawa is currently under-serviced for hospital beds.(More)