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BACKGROUND Osteoporosis is a major public health problem, mainly quantified by low bone mineral density (BMD). The majority of BMD variation is determined by genetic effects. A pilot whole genome linkage scan (WGS) was previously reported in 53 white pedigrees with 630 subjects. Several genomic regions were suggested to be linked to BMD variation. (More)
BACKGROUND The vitamin D receptor (VDR) gene is important to human stature, as it mediates metabolic pathways, calcium homeostasis, and phosphate homeostasis, which influence growth. METHODS We examined the relationship between VDR and adult height in 1873 white subjects from 406 nuclear families. Four SNPs, namely -4817A/G at intron 1, FokI C/T at exon 2(More)
BACKGROUND The haplotype based association method offers a powerful approach to complex disease gene mapping. In this method, a few common haplotypes that account for the vast majority of chromosomes in the populations are usually examined for association with disease phenotypes. This brings us to a critical question of whether rare haplotypes play an(More)
Osteoporosis is a common bone disease inflicting about 40% of women and 12% of men at some point during life. It is mainly characterized by the unbalanced loss of bone mass with decreased density and deteriorated bone microarchitecture, leading to osteoporotic fracture. The social economic burden of osteoporosis is so large that its etiology, prevention and(More)
Background:Vitamin D-binding protein (DBP) gene is well known for its function on glucose and vitamin D metabolism in human populations. Previous studies suggested that the in vivo DBP level may play a role in the etiology of obesity. However, few studies explored the contribution of DBP gene to the variance of obesity phenotypes.Objective:To investigate(More)
BACKGROUND Bone size is an important determinant of bone strength and is under strong genetic control. OBJECTIVE To identify quantitative trait loci (QTL) for areal bone size variation, a large-scale genomewide linkage scan was carried out in 451 Caucasian families. PARTICIPANTS AND METHODS Of 4124 people with phenotypes, 3899 were genotyped with 410(More)
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