D H Morison

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This is the report of a series of eight patients with pulmonary hypertension (primary and secondary) who delivered at the McMaster University Medical Centre between 1978 and 1987. Seven of the eight patients delivered vaginally and had a successful outcome. The eighth patient was admitted as an emergency and died shortly after Caesarean section under(More)
This study compares a continuous infusion technique with intermittent "top-up" doses using 0.25 per cent bupivacaine for epidural analgesia for labour and delivery in healthy primiparous patients. Sixty women were randomized into two groups, A (continuous) and B (intermittent). Twenty-eight patients in Group A and 29 in Group B completed the study. We(More)
Preoperative cimetidine, ranitidine, or placebo were administered, orally or intravenously to 190 patients in a double-blind study. The volume and pH of gastric aspirate samples, obtained after tracheal intubation and before extubation, were measured. Both cimetidine and ranitidine produced higher mean pH levels and thus fewer patients "at risk" should(More)
A double-blind comparison of carbonated bupivacaine and bupivacaine hydrochloride in extradural anaesthesia was performed in 40 patients. No significant differences in the onset times, sensory blockade, motor blockade and duration of anaesthesia were demonstrated. Carbonated bupivacaine does not appear to offer any advantage over the hydrochloride salt for(More)
Three regimens of oral zomepirac premedication - 100 mg and 200 mg administered one hour preoperatively, and 100 mg administered 30 minutes preoperatively - were compared in terms of the control of postoperative pain. Primary outcomes were postoperative analgesic requirements, pain intensities and side effects. Sixty patients undergoing laparoscopic(More)
Plasma concentrations of minaxolone were measured in 15 female patients during and for up to 3 hours after a minaxolone and nitrous oxide anesthetic. Nine patients received a single dose and six patients two or three doses of minaxolone. Plasma minaxolone decay can be described by two-compartment kinetics. Distribution is rapid, with a mean half-life of 2.1(More)
Preoperative cimetidine 300 mg or ranitidine in 50 and 100 mg doses were administered intramuscularly to 120 patients in a randomized double-blind study. The volume and pH of gastric aspirate samples obtained after tracheal intubation and before extubation were measured. The pH of gastric aspirate was higher following ranitidine 100 mg than ranitidine 50 mg(More)
This study was designed to test whether there is any difference in the placental transfer of bupivacaine or lidocaine in the early compared to the late preterm maternal/fetal sheep preparation; and whether the premature lamb fetus reacts to a steady state local anaesthetic infusion differently from the same lamb near term. Eleven ewes were studied in two(More)