Learn More
This study analyzed the change in breast density in women receiving tamoxifen treatment using 3-D MRI. Sixteen women were studied. Each woman received breast MRI before and after tamoxifen. The breast and the fibroglandular tissue were segmented using a computer-assisted algorithm, based on T1-weighted images. The fibroglandular tissue volume (FV) and(More)
PURPOSE Quantitative breast density is known as a strong risk factor associated with the development of breast cancer. Measurement of breast density based on three-dimensional breast MRI may provide very useful information. One important step for quantitative analysis of breast density on MRI is the correction of field inhomogeneity to allow an accurate(More)
PURPOSE To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences. METHODS Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of different morphological patterns ("central" and "intermingled"(More)
PURPOSE In breast MRI, skin and fibroglandular tissue commonly possess similar signal intensities, and as such, the inclusion of skin as dense tissue leads to an overestimation in the measured density. This study investigated the impact of skin to the quantitative measurement of breast density using MRI. METHODS The analysis was performed on the normal(More)
PURPOSE Mammographic density and breast parenchymal patterns (the relative distribution of fatty and fibroglandular tissue) have been shown to be associated with the risk of developing breast cancer. Percent breast density as determined by mammography is a well-established risk factor, but on the other hand, studies on parenchymal pattern have been scarce,(More)
PURPOSE To compare the breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from breast MRI of the same women using four different MR scanners. METHODS The study was performed in 34 healthy Asian volunteers using two 1.5T (GE and Siemens) and two 3T (GE and Philips) MR scanners. The BV, FV, and PD were measured on(More)
This study presents a finite element-based computational model to simulate the three-dimensional deformation of a breast and fibroglandular tissues under compression. The simulation was based on 3D MR images of the breast, and craniocaudal and mediolateral oblique compression, as used in mammography, was applied. The geometry of the whole breast and the(More)
PURPOSE To develop a computer-based algorithm for detecting blood vessels that appear in breast dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), and to evaluate the improvement in reducing the number of vascular pixels that are labeled by computer-aided diagnosis (CAD) systems as being suspicious of malignancy. MATERIALS AND METHODS The(More)
We report on a vertical adiabatic transition between silica planar waveguides and electro-optic (EO) polymer. Gray-scale lithography was used to pattern a polymer transition with an exponential profile. Excess losses of the order of 1 dB were measured, and good mode matching to simulation was observed. This configuration, which married the advantages of(More)