D. G. Norris

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As neuroinflammation is an early event in the pathogenesis of Alzheimer's disease, new selective anti-inflammatory drugs could lead to promising preventive strategies. We evaluated the safety, tolerability, pharmacokinetics and pharmacodynamics of CHF5074, a new microglial modulator, in a 12-week, double-blind, placebo-controlled, parallel groups, ascending(More)
•DTI can provide information on microstructural white matter integrity.•White matter microstructural integrity is not related to cognitive decline in SVD.•These results are in contrast with cross-sectional findings.•Other factors than white matter microstructural damage underlie this cognitive decline.
Institute for Neuroradiology, Christian-Albrechts-Universität, UK-SH, Kiel, Germany , C.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands, Erwin L. Hahn Institute for Magnetic Resonance(More)
Introduction Continuous artery-selective spin labeling (CASSL) [1] is one technique to image perfusion territories of cerebral arteries. To date, CASSL was only applied to major brain feeding arteries, but, recently, empirical findings have demonstrated that this method is even capable of selectively label the blood of individual branching intracranial(More)
Introduction Several methods in perfusion imaging are able to image perfusion territories of cerebral arteries [1]. Most of them only allow for labeling of extracranial arteries like leftand right-sided carotids or vertebral arteries. However, a clear delineation of the border between smaller territories is not possible and often impedes a reliable(More)
This study aims at the effects of traumatic brachial plexus lesion with root avulsions (BPA) upon the organization of the primary motor cortex (M1). Nine right-handed patients with a right BPA in whom an intercostal to musculocutaneous (ICN-MC) nerve transfer was performed had post-operative resting state fMRI scanning. The analysis of empirical functional(More)
M. Elschot, S. A. Rombouts, M. J. Malessy, C. A. Schimmelpenninck, M. J. van Osch, I. Toni, D. G. Norris, M. A. van Buchem, and P. F. Buur Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Department of(More)
To assess the response rates and toxicity of AZQ in children with recurrent brain and other malignant solid tumors, a phase II study was implemented by the Pediatric Oncology Group. Eligible patients received AZQ 18 mg/M2/week i.v. for 4 doses followed by a 2 week rest period. Each dose was given over four hours (1/3 over the initial 20 minutes). After the(More)
Introduction: Pseudo-continuous arterial spin labeling (psCASL) is a newly proposed technique, which employs a train of discrete RF pulses that mimics continuous ASL, but has a much lower SAR [1]. A couple of different methods have been proposed that allow for imaging of perfusion territories [2-4]. These adaptations employ additional gradient pulses(More)
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