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Isolates of the 3 biovariants of Mycobacterium fortuitum exhibited 3 patterns of resistance when tested against 9 aminoglycosides. Examination of cell lysates from the 3 groups revealed 15/15 isolates to contain an aminoglycoside acetyltransferase (AAC) resembling AAC (3)-III or (3)-IV found in bacterial species. The enzyme did not appear to confer(More)
Interpretive criteria for cefotetan in vitro susceptibility testing appear to be clinically relevant when applied to aerobic bacteria. To determine whether the same was true for anaerobic bacteria, we conducted a retrospective analysis of intraabdominal, gynecologic, and skin and skin structure infections treated with cefotetan. Of the infections, 202(More)
Possible mechanisms of drug resistance of Mycobacterium fortuitum and Mycobacterium chelonei to antibacterial agents were investigated. Single-step mutational frequencies were low (generally less than or equal to 10(-7] for cefoxitin, doxycycline, erythromycin, and sulfamethoxazole and relatively high (10(-4) to 10(-7] for kanamycin and amikacin.(More)
The in vitro antianaerobic activity of cefotetan was compared with that of chloramphenicol, clindamycin, cefoxitin, and penicillin in a multicenter study. Both agar dilution and broth microdilution testing procedures, as described by the National Committee for Clinical Laboratory Standards (NCCLS), were employed; a total of 1,377 strains were examined.(More)
Two clinical isolates of Serratia marcescens resistant to aminoglycoside-aminocyclitols and other antibiotics have been examined for aminoglycoside-modifying enzymes. Both strains were amikacin-resistant, and this resistance was mediated by an acetyltransferase AAC(6'). S. marcescens 737 contains a single conjugative plasmid, pUZ 737, of 135 kilobases,(More)
The neutralizing ability of Difco Bacto Penase, BBL Penicillinase, and Genzyme beta-lactamase for penicillin G, oxacillin, cephalothin, cefazolin, ceftazidime, ceftriaxone, cefotaxime, imipenem, and meropenem was determined in an agar medium. Trypticase soy agar plates (20 mL) containing 200 MU/L Difco Penase, 200 MU/L BBL Penicillinase, or 2 vials/L of(More)
Reference values for quality control of in vitro susceptibility tests with cefotetan against anaerobic bacteria were determined in two independent multilaboratory studies with the approved National Committee for Clinical Laboratory Standards agar dilution method and three control strains (Bacteroides fragilis ATCC 25285, Bacteroides thetaiotaomicron ATCC(More)
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