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Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

• Giacomo Bellani, John G. Laffey, +13 authors Antonio Pesenti
• JAMA
• 2016

IMPORTANCE Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES To evaluate intensive… (More)

Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1).

• Moronke A Noah, G. J. Peek, +19 authors Kathryn M. Rowan
• JAMA
• 2011

CONTEXT Extracorporeal membrane oxygenation (ECMO) can support gas exchange in patients with severe acute respiratory distress syndrome (ARDS), but its role has remained controversial. ECMO was used… (More)

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.

• Murali Shyamsundar, Scott Thomas William McKeown, +8 authors D F Mcauley
• American journal of respiratory and critical care…
• 2009

RATIONALE Simvastatin inhibits inflammatory responses in vitro and in murine models of lung inflammation in vivo. As simvastatin modulates a number of the underlying processes described in acute lung… (More)

A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study).

• Thelma R Craig, Martin J Duffy, +4 authors D F Mcauley
• American journal of respiratory and critical care…
• 2011

RATIONALE There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying processes important in ALI. … (More)

Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.

• James A. Frank, Charlie M Wray, D F Mcauley, Reto Albert Schwendener, Michael A. Matthay
• American journal of physiology. Lung cellular and…
• 2006

In patients requiring mechanical ventilation for acute lung injury or acute respiratory distress syndrome (ARDS), tidal volume reduction decreases mortality, but the mechanisms of the protective… (More)

Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury.

• Thelma R Craig, Martin J Duffy, +4 authors D F Mcauley
• Critical care medicine
• 2010

OBJECTIVES Acute lung injury and the acute respiratory distress syndrome are characterized by noncardiogenic pulmonary edema, which can be assessed by measurement of extravascular lung water.… (More)

Discrepancies between clinical and postmortem diagnoses in critically ill patients: an observational study

• Gavin D Perkins, D F Mcauley, Sarah Davies, Fang Gao
• Critical care
• 2003

INTRODUCTION The autopsy has long been regarded as an important tool for confirming the clinical cause of death, education and quality assurance. Concerns surrounding informed consent and the… (More)

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

• Megan V. Jackson, Thomas J. Morrison, +5 authors Anna D Krasnodembskaya
• Stem cells
• 2016

Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The mechanism of this effect is not… (More)

The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial.

• Gavin D Perkins, D F Mcauley, David R Thickett, Fang Gao
• American journal of respiratory and critical care…
• 2006

RATIONALE Experimental data suggest that manipulation of alveolar fluid clearance with beta-agonists can accelerate the resolution of alveolar edema and improve survival. OBJECTIVE To determine if… (More)

Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial

• Fang Gao Smith, Gavin D Perkins, +5 authors Sarah E Lamb
• The Lancet
• 2012

BACKGROUND In a previous randomised controlled phase 2 trial, intravenous infusion of salbutamol for up to 7 days in patients with acute respiratory distress syndrome (ARDS) reduced extravascular… (More)

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