D. F. Hartley

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EMT6/Ro spheroids approximately 500 microns in diameter were subjected to photodynamic therapy administered at various incident radiation fluence rates. Following 24 h incubation with 10 micrograms/ml Photofrin, groups of spheroids were irradiated at 630 nm with an identical fluence of 60 J/cm2, delivered at fluence rates ranging from 25 to 200 mW/cm2.(More)
Objective. The aim of this study was to assess the capability of high-resolution images obtained with a commercially available pelvic phased-array surface coil to demonstrate normal hip anatomy. Design. We retrospectively analyzed the oblique coronal magnetic resonance (MR) images of hips of 36 consecutive patients acquired on a 1.5-T clinical imager using(More)
UNLABELLED The high affinity streptavidin (or avidin)/biotin system is being investigated for imaging and radiotherapy procedures. Streptavidin (SA) and avidin exhibit markedly different pharmacokinetics, with avidin clearing from the blood much faster than SA. To optimize blood clearance kinetics, SA and avidin were biochemically modified and analyzed in(More)
OBJECTIVE This study identified the extent of inter- and intraobserver variation in assessing intrarenal Doppler waveform parameters. SUBJECTS AND METHODS Optimized Doppler waveforms from the interlobar arteries of five healthy volunteers were recorded. The waveforms were digitized for off-line evaluation by six observers. Using the same set of waveforms,(More)
PURPOSE The purpose of this study was to evaluate the utility of sonography in distinguishing between mechanical and nonmechanical causes for renal transplant dysfunction. METHODS We reviewed all ultrasound examination reports (n = 286) for 63 consecutive patients who received 64 renal transplants. We assessed the sensitivity and specificity of different(More)
The file handling facility now in use on the Titan computer at the University Mathematical Laboratory, Cambridge provides storage for data over indefinitely long periods of time and yet contrives to make that data available on demand. An 8 million word disc is augmented by the use of magnetic tape. The organization of this available space is entirely a(More)
RATIONALE AND OBJECTIVES We evaluated the changes in the down-stream Doppler waveforms caused by a proximal stenosis in the main renal artery of dogs. METHODS Renal parenchymal arterial waveforms downstream from mild (< 50%), moderate (50-75%), and severe (76-95%) stenoses were compared with nonstenotic baseline waveforms in five mongrel dogs. Waveform(More)
An enzyme-linked assay was developed to quantify serum biotin concentrations in experimental animals and humans. With this assay the effect on serum biotin concentration after intravenous injection of streptavidin or the addition of avidin to food was studied in rabbits and dogs. Intravenous injection of streptavidin reduced serum biotin values quickly but(More)