D F Bogdanski

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In a low-sodium, choline+ (Ch+) medium, rat heart slices, that were labelled in vivo with [3H]norepinephrine, exhibited a delayed Ca2+-dependent release of radioactivity, these radioactive compounds consisted of both amines and deaminated metabolites. The Ca2+-dependent release of radioactivity was largely blocked by cocaine suggesting that the release may(More)
Rat hearts were labelled with [3H]norepinephrine in vivo. Slices of ventricles were prepared, preincubated in Krebs-HCO3 medium (KRB), and then incubated in a Na+-deficient, choline+-Krebs HCO3 (Ch+-Ca2+). The choline+-Krebs HCO3 medium induced a delayed neurosecretion which could be inhibited by either one of the blockers of the uptake of NE, cocaine or(More)
Reports from this laboratory have suggested that the secretion of norepinephrine (NE) in slices of ventricle from the rat heart, incubated in a medium of choline and Ca2+ (Ch+-Ca2+) deprived of Na+, is mediated by the outward transport of NE (blocked by cocaine) from synaptic vesicles fused or attached to the axolemma. Lithium (and reserpine), block the(More)
A Ca++-dependent secretion of norepinephrine ([3H]NE) was evoked in adrenergic nerve endings in rat heart ventricle slices incubated in a modified Krebs-HCO3 medium containing choline Cl as the replacement for NaCl (Ch+-Ca++). Exogenous ATP inhibited secretion and lithium ion, a known inhibitor of NE uptake dependent upon Mg++-ATPase activity in vesicles(More)
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