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Glycine (5 X 10(-5) M) stimulated the spontaneous release of 3H-DA continuously synthesized from 3H-tyrosine in striatal slices. This effect was calcium-dependent and significantly reduced in the presence of strychnine (10(-5) M). The glycine-evoked release of 3H-DA was no longer seen in the presence of tetrodotoxin (5 X 10(-7) M).
Young rats were fed on an essential fatty acid (EFA)-deprived diet for 6 weeks after weaning. Their pituitary was removed and adenohypophyseal cells dispersed and maintained in culture. Membrane lipids were analyzed and basal and stimulated levels of hormone secretion were measured after 4-day incubation in a culture medium containing or not 160 microM… (More)
Abstract The potential involvement of arachidonic acid metabolites in the regulation of adenohypophyseal secretion was analysed on pituitary glands from male rats incubated in the presence of various inhibitors with different mechanisms of action: two inhibitors of phospholipase A(2) (parabromophenacylbromide, PB and compound CB 874), an inhibitor of… (More)