D. E. Moulton

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Airway remodeling in patients with chronic asthma is characterized by a thickening of the airway walls. It has been demonstrated in previous theoretical models that this change in thickness can have an important mechanical effect on the properties of the wall, in particular on the phenomenon of mucosal folding induced by smooth muscle contraction. In this(More)
We investigate the draining of a vertical magnetic soap film in the presence of a strong, nonuniform magnetic field. A colloidal suspension of magnetic nanoparticles in a regular soap solution yields a magnetic soap solution, from which a soap film is formed across an isolated frame. Experiments demonstrate that with a strong magnet placed above the frame,(More)
Wound healing is a complex process in which a sequence of interrelated phases contributes to a reduction in wound size. For diabetic patients, many of these processes are compromised, so that wound healing slows down. In this paper we present a simple ordinary differential equation model for wound healing in which attention focusses on the dominant(More)
How mechanical and biological processes are coordinated across cells, tissues, and organs to produce complex traits is a key question in biology. Cardamine hirsuta, a relative of Arabidopsis thaliana, uses an explosive mechanism to disperse its seeds. We show that this trait evolved through morphomechanical innovations at different spatial scales. At the(More)
Surface tension and electrostatic forces dominate the behavior of many micro and nano scale systems. Understanding interactions between these forces may therefore be of great utility in a number of engineering systems. We investigate one such interaction by subjecting an elastic membrane suspended between two parallel rings to an axially symmetric electric(More)
Convergent evolution is a phenomenon whereby similar traits evolved independently in not closely related species, and is often interpreted in functional terms. Spines in mollusk seashells are classically interpreted as having repeatedly evolved as a defense in response to shell-crushing predators. Here we consider the morphogenetic process that shapes these(More)
We develop a model of wound healing in the framework of finite elasticity, focussing our attention on the processes of growth and contraction in the dermal layer of the skin. The dermal tissue is treated as a hyperelastic cylinder that surrounds the wound and is subject to symmetric deformations. By considering the initial recoil that is observed upon the(More)
Seashells grow through the local deposition of mass along the aperture. Many mathematical descriptions of the shapes of shells have been provided over the years, and the basic logarithmic coiling seen in mollusks can be simulated with few parameters. However, the developmental mechanisms underlying shell coiling are largely not understood and the ubiquitous(More)
The coupling between community composition and climate change spans a gradient from no lags to strong lags. The no-lag hypothesis is the foundation of many ecophysiological models, correlative species distribution modelling and climate reconstruction approaches. Simple lag hypotheses have become prominent in disequilibrium ecology, proposing that(More)
The bladder is a complex organ that is highly adaptive to its mechanical environment. The umbrella cells in the bladder uroepithelium are of particular interest: these cells actively change their surface area through exo- and endocytosis of cytoplasmic vesicles, and likely form a critical component in the mechanosensing process that communicates the sense(More)