D E Huw Llewelyn

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Recessive dystrophic epidermolysis bullosa (RDEB) is characterised by progressive childhood hand syndactyly and flexion contractures, which can be managed surgically but require split thickness autografts to facilitate satisfactory postoperative healing. We report on the partial substitution, for autografts, of improved composite cultured skin (CCS)(More)
1. The process of diagnosis by elimination in terms of probabilities is analysed mathematically. 2. A piece of evidence which is only associated with a small number of differential diagnoses is of particular importance. 3. To deal with a differential diagnosis, a feature is required which occurs commonly in a postulated diagnosis but rarely in its rivals,(More)
A probability theorem is described which identifies the factors to be considered when applying the principle of logical elimination to probabilistic diagnosis. The proof is based only on the multiplication, addition and universal bound axioms of probability. When new tests are being designed from knowledge of disease mechanisms, criteria based on the(More)
Human attention may be guided by representations held in working memory (WM) and also by priming from implicit memory. Neurophysiological data suggest that WM and priming may be associated with distinct neural mechanisms, but this prior evidence is only correlative. Furthermore, the role of the visual cortex in attention biases from memory remains unclear,(More)
A new type of clinical summary, produced by copying standard descriptions of diseases on to a computer screen and editing them to match a patient's findings and diagnoses, was updated and reprinted as the patient's condition changed in the ward or as an outpatient. When this method was used to produce typed medical discharge summaries over a three month(More)
HYPOTHESIS The efficacy of a treatment in a clinical trial depends in part on where the cut-off point is placed for the test result used to select patients for the trial, and this applies to irbesartan in the Irbesartan Microalbuminuria II (IRMA II) trial for preventing nephropathy. PATIENTS AND METHODS Patients in the IRMA II trial were stratified into(More)
OBJECTIVES To perform a prospective study to compare the ability of magnetic resonance imaging (MRI) and computer assisted tomography (CT) to predict the position of a tumour within the pituitary fossa and to assess the clarity of the image generated by the two modalities in patients with suspected pituitary microadenomas. DESIGN Nineteen patients were(More)