D Collette Williams

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In a survey of 900 Dalmatian dogs, brainstem auditory-evoked responses (BAER) and clinical observations were used to determine the incidence and sex distribution of bilateral and unilateral BAER abnormalities and their association with heterochromia iridis (HI). To assess the efficacy of BAER testing in guiding breeding programs, data from 749 dogs(More)
Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for(More)
BACKGROUND The influence of sleep on the equine electroencephalogram (EEG) has not been well documented. HYPOTHESIS The objectives were to develop a noninvasive method of electrode placement for recording the EEG in horses and to establish normal EEG parameters for the various states of vigilance. Findings are compared with previously published reports on(More)
OBJECTIVE To determine the neurologic effects of reduced intake of phenylalanine and tyrosine in black-haired cats. ANIMALS 53 specific pathogen-free black domestic shorthair cats. PROCEDURE Cats were fed purified diets containing various concentrations of phenylalanine and tyrosine for < or = 9 months. Blood samples were obtained every 2 months for(More)
Endoneurial capillaries in nerve biopsies from 12 adult diabetic cats with varying degrees of neurological dysfunction were examined for evidence of microvascular pathology and compared to nerves obtained at necropsy from 7 adult non-diabetic cats without clinical evidence of neurological dysfunction. As reported previously [Mizisin, A.P., Nelson, R.W.,(More)
A case of congenital encephalocele of the middle ear presenting as a conductive hearing loss is reported. In retrospect it is possible that CT scanning with metrizimide contrast studies may have been helpful in establishing the diagnosis (Cooper and Kassel, 1982). However, it is stressed that even in the absence of radiological abnormality of the temporal(More)
OBJECTIVE Prevention of rejection and preservation of graft function remain as obstacles to clinical small intestinal transplantation (SIT). This study evaluated the effects of combined immunosuppressive agents (FK506, Rapamycin, and Mycophenolate Mofetil) on intestinal function and animal well being. METHODS Screening for additive toxicity was done in(More)
Paroxysmal discharges (PD) consisting of spikes, multiple spike complexes, sharp waves, multiple sharp-wave complexes, and spike-and-slow-wave complexes can be recorded in the interictal electroencephalograms of sedated epileptic dogs. With appropriate methods, focal PD can be detected and the hemisphere of origin and rostrocaudal location of their sources(More)
BACKGROUND Botulism is a potentially fatal paralytic disorder for which definitive diagnosis is difficult. OBJECTIVES To determine if repetitive stimulation of the common peroneal nerve will aid in the diagnosis of botulism in foals. ANIMALS Four control and 3 affected foals. METHODS Validation of the test in healthy foals for its comparison in foals(More)