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Adult wild rabbits from the southern UK, previously unexposed to rabbit haemorrhagic disease (RHD), were experimentally challenged with a UK strain of the virus in laboratory conditions. Initial serum antibodies were measured by an haemagglutination inhibition test and all seropositive rabbits, with reciprocal titres > 10, were protected against fatal(More)
A variant strain of rabbit haemorrhagic disease virus, designated "Rainham', originally isolated from a small localized outbreak of the disease in southern England, has been further examined and compared with conventional reference strains. The virus originally failed to haemagglutinate in standard conditions at normal temperature and consistently lacked HA(More)
Porcine epidemic diarrhoea type II was reproduced in experimental pigs of various ages by oral dosing with minced intestine from a naturally occurring case of the disease. Virus-like particles which probably represent an unidentified coronavirus were seen by electron microscopy in the faeces and intestinal epithelium of infected animals.
Comparative antigenic and nuclei acid analyses were carried out on two new atypical rotavirus isolates coming respectively from chickens (D/132) and pigs (E/DC-9). Indirect immunofluorescence showed that each virus carried different group antigens which were also distinct from those of previously described rotavirus groups. By genome profile analysis each(More)
The virus recovered from cases of European brown hare syndrome in the U.K. contains one major capsid protein of approximately 60 k molecular weight and morphologically resembles known caliciviruses. It has been compared with a European isolate of rabbit haemorrhagic disease calicivirus and, although it shows some antigenic similarity, it is not identical.(More)
Studies on the aetiological agents of rabbit haemorrhagic disease (RHD) and European brown hare syndrome show that the viruses responsible for these infections can be placed in the family Caliciviridae. Established members of this group are vesicular exanthema virus (prototype), San Miguel sea lion virus and feline calcivirus. The human hepatitis E virus(More)
In April 1992, an investigation of sudden, increased mortality among adult rabbits on two premises in the south of England revealed clinical and pathological findings consistent with rabbit haemorrhagic disease. Virus particles morphologically resembling caliciviruses were detected in the livers of affected rabbits, and further studies confirmed the first(More)