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BACKGROUND Although a few studies have investigated delays in diagnosis and treatment among children and adolescents with cancer, this has never been subject of study in South Africa. Early diagnosis is fundamental as it allows timely treatment and prevents unnecessary complications. PROCEDURES Combined prospective and retrospective study of 194 children(More)
OBJECTIVES In 2008 the South African Children's Cancer Study Group decided to review the epidemiology, management, and chemotherapy response of HIV-positive children with malignancy. METHODS This is a retrospective analysis of data collected from the records of HIV-positive children diagnosed with malignancy at 7 university-based pediatric oncology units(More)
AIM To identify ethnic group differences in the prognostic of Hodgkin lymphoma (HL) in South African children. PATIENTS AND METHODS In order to create a larger database, cases were pooled from two South African hospitals: Tygerberg in the Western Cape and Bloemfontein Academic Complex in Free State. Self-assigned ethnicity was used to allocate the(More)
BACKGROUND Little is known on the risk of cancer in HIV-positive children in sub-Saharan Africa. We examined incidence and risk factors of AIDS-defining and other cancers in pediatric antiretroviral therapy (ART) programs in South Africa. METHODS We linked the records of 5 ART programs in Johannesburg and Cape Town to those of pediatric oncology units,(More)
BACKGROUND There is insufficient research into the clinical presentation and outcome after treatment in children with Burkitt's lymphoma (BL) who are also HIV infected, by comparison with those who are not infected. PATIENTS AND METHODS This retrospective study analyzed 15 HIV infected children with BL by comparison with 30 children with BL but not(More)
BACKGROUND There is insufficient research into the state of paediatric oncology in African countries. OBJECTIVES The purpose of this study was to analyse the state of paediatric oncology between 1995 and 2004 in Côte d'Ivoire. METHODS This retrospective descriptive study analysed all patients under the age of 18 who were diagnosed with cancer in Côte(More)
UNLABELLED BACKGROUND IN ADULTS,: HIV increases the risk of certain cancers known, or thought, to have an underlying infectious etiology; the impact on the risk of cancer in children is less clear. METHODS Here, we report results of an on-going study at four pediatric oncology centers in South Africa in which children diagnosed with cancer are tested(More)
Since Thomas Hodgkin's paper, entitled "On Some Morbid Appearances of the Absorbent Glands and Spleen", published in 1832, an enormous body of research on lymphomas has developed. Even more research is required, however, in order to completely prevent or treat these neoplasms of the lymphocytes.
The creation and implementation of national cancer control plans is becoming increasingly necessary for countries in Africa, with the number of new cancer cases per year in the continent expected to reach up to 1·5 million by 2020. Examples from South Africa, Egypt, Nigeria, Ghana, and Rwanda describe the state of national cancer control plans and their(More)