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Redundancy-aware learning of protein structure-function relationships by Drew Bryant The protein kinases are a large family of enzymes that play a fundamental role in propagating signals within the cell. Because of the high degree of binding site similarity shared among protein kinases, designing drug compounds with high specificity among the kinases has(More)
Mapping the Structural Landscape of Protein Families with Geometric Feature Vectors by Drew Bryant This thesis describes two key results that can be used separately or in combination for protein function analysis. The Family-wise Analysis of SubStructural Templates (FASST) method uses all-against-all substructure comparison to determine family-wide subgroup(More)
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