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The discovery of orally available thrombin inhibitors: optimisation of the P1 pharmacophore.
Thrombin inhibitors have been designed with the replacement of the strongly basic guanidine P1 pharmocophore with a group that exploits the lipophilicity of the S1 pocket. The approach has lead toExpand
  • 6
Studies towards the identification of potent, selective and bioavailable thrombin inhibitors.
The application of selection criteria, based on potency and physicochemical parameters, to a candidate library of thrombin inhibitors is described. The utility of the approach is exemplified by theExpand
  • 7
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