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Methods • Network meta-analyses are commonly conducted within a Bayesian framework to enable the ranking of interventions, based on the probability of each treatment to be associated with the best efficacy. • Multivariate models have been developed to deal with correlation between outcomes as they allow to account for the within-study correlation between(More)
• ORA vs. B>1 indicates a higher response rate in favour of treatment A. • The DIC (Deviance Information Criterion) is commonly used to select fixed vs. random effects model • DIC represents a trade-off between model adequacy and complexity (i.e. complex models, for example a random effect vs a fixed effect model, are penalised) • The model associated with(More)
Objectives: To estimate the efficacy and safety of glycopirronium-indacaterol (GLN/IND) as maintenance therapy for moderate to severe chronic obstructive pulmonary disease (COPD) compared to other first-line treatments, through a systematic review and meta-analysis. MethOds: A detailed search was performed in eight electronic databases (MEDLINE, EMBASE,(More)
• An ad-hoc search of the literature was conducted to identify existing checklists. Items from these checklists were extracted and critically reviewed. • Recommendations from NICE [1,2] as well as existing NICE submissions and corresponding comments from the evidence review groups (ERG) were used to develop the checklist, which was then tested by(More)
outcomes evaluated included change from baseline in trough forced expiratory volume in 1 second (FEV1) and COPD exacerbations leading to hospitalizations. Efficacy of tiotropium was presented as the mean difference to placebo. Results: Difference in change from baseline in FEV1 versus placebo was evaluated in 21 RCTs. The relative effect of tiotropium(More)
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