D. Baker

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The prediction of protein 3D structure has become a hot research area in the post-genome era, through which people can understand a protein's function in health and disease, explore ways to control its actions and assist drug design. Many protein structure prediction approaches have been proposed in past decades. Among them, Rosetta is one of the best(More)
Toll-like receptors (TLRs) are key receptors of the innate immune system which are expressed on immune and nonimmune cells. They are activated by both pathogen-associated molecular patterns and endogenous ligands. Activation of TLRs culminates in the release of proinflammatory cytokines, chemokines, and apoptosis. Ischaemia and ischaemia/reperfusion (I/R)(More)
In the Western world, peripheral vascular disease (PVD) has a high prevalence with high morbidity and mortality. In a large percentage of these patients, lower limb amputation is still required. Studies of ischaemic skeletal muscle disclosed evidence of endogenous angiogenesis and adaptive skeletal muscle metabolic changes in response to hypoxia. Chemokines(More)
Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO(More)
Peripheral Arterial Disease (PAD) is a cause of significant morbidity and mortality in the Western world. Risk factor modification and endovascular and surgical revascularisation are the main treatment options at present. However, a significant number of patients still require major amputation. There is evidence that nitric oxide (NO) and its endogenous(More)
1. Overview Cardiovascular disease is a leading cause of morbidity and mortality with considerable financial impact worldwide. This special issue explores recent developments and novel strategies to target emerging risk factors central to the complex molecular mechanisms regulating the cardiovas-cular disease process. The concept was prompted by discussions(More)
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