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A set of over 20 dynamic mouse FDG microPET images has been collected experimentally at UCLA and is made available to the public on the Internet. Accompanying each dynamic image set also is the radioactivity measurements of multiple sequential blood samples taken during the study. The data are expected to be useful for investigators who want to know more(More)
Currently available diagnostic techniques can be unreliable in the diagnosis of delayed fracture healing in certain clinical situations, which can lead to increased complication rates and costs to the health care system. This study sought to determine the utility of positron emission tomography (PET) scanning with 18F-fluoride ion, which localizes in(More)
Improved resolution with iterative maximum a posteriori (MAP) image reconstruction is promising; however in the past, image values varied based on the detected total counts, therefore filtered backprojection (FBP) has remained the first choice for quantitation using microPET. To determine if MAP can be utilized to generate accurate noninvasive blood and(More)
PETbox is designed to be a low cost and easy to use bench top small animal PET scanner dedicated for high throughput quantitative pharmacokinetic and pharmacodynamic studies. To achieve this goal, the scanner is integrated with a complete animal management system that provides life support including reproducible positioning, temperature control, anesthesia,(More)
Despite recent developments in high resolution small animal PET, cardiac studies in mice are still of limited quality due to the small size of the imaged organ and motion within the cardiac and respiratory cycle. By gating for one or both motions an improvement of the quantitative PET-data and images can be expected. We used a data acquisition and analysis(More)
Image-derived input functions (EDIF) are desirable for quantifying biological functions in mouse microPET studies. Due to difficulties in taking many blood samples from each mouse, conventional IDIF validation method of comparing blood samples with IDIF in a single animal is not applicable. A new approach that requires statistical testing on data of(More)
In this study, we evaluated the temporal resolution of a new microPET system in mice. We then applied the high resolution capability for determining the cardiovascular transit time which is an important physiological parameter in the study of animal models of cardiovascular disease. Two groups of mice, group 1 (n=12) with high body weight and group 2 (n=10)(More)
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