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Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North European extraction, and control(More)
OBJECTIVE To determine whether the features of syndrome X are more common in first-degree relatives of non-insulin-dependent diabetes mellitus (NIDDM) patients than in control subjects with no family history of diabetes. RESEARCH DESIGN AND METHODS A total of 154 first-degree relatives from 60 families with two or more NIDDM patients and 154 age- and(More)
The aetiology of NIDDM is uncertain, although family and twin studies indicate an important role for genetic factors in disease onset. The function and position of IRS-1 within the insulin signalling pathway make it a prime candidate gene for the development of insulin resistance and NIDDM. Insulin resistant families were identified by studying unaffected(More)
  • D Humphriss
  • 1987
This report describes three studies of drivers' vision which have recently been carried out in South Africa. In the first, it was found that younger myopes constituted a substantial fraction of those drivers who failed to reach the acuity standards required for a South African driving licence: the acuity of almost all these drivers could be raised to an(More)
  • D Humphriss
  • 1982
An experiment was designed that demonstrates that in a state of normal binocular vision a low plus sphere fogging the vision to 6/12 (20/40) produces an inhibition of the central foveal cones in the fogged eye. This inhibition is a natural process that can be switched on and off rapidly so that the fovea receiving the clearer image can examine it and hence(More)
Cardiovascular disease is the leading cause of death in non-insulin dependent diabetes mellitus and first degree relatives of such patients are at increased risk of developing diabetes and cardiovascular disease. The aim of the present study was to determine whether lipid abnormalities occur in normoglycaemic relatives of non-insulin dependent diabetic(More)