D. B. Goldstein

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One general approach for assessing whether phenotypic variation is due to selection is to test its correlation with presumably neutral molecular variation. Neutral variation is determined by population history, the most likely alternative explanation of spatial genetic structure, whereas phenotypic variation may be influenced by the spatial pattern of(More)
It has recently been suggested that observed levels of variation at microsatellite loci can be used to infer patterns of selection in genomes and to assess demographic history. In order to evaluate the feasibility of these suggestions it is necessary to know something about how levels of variation at microsatellite loci are expected to fluctuate due simply(More)
Animal models of the alcohol-dependent state, now readily available in many species, show that a withdrawal reaction can be produced whenever intoxication has been continuously maintained, even for short periods of time. The development of the tolerant/dependent state resembles a physiological adaptation in two ways: (1) the animal is no longer much(More)
Wright first introduced the idea that random genetic drift and classical mass-action selection might combine in such a way as to allow populations to find the highest peak in complicated adaptive surfaces. His theory assumes large but structured populations, in which mating is spatially local. If gene flow is sufficiently low, and the subpopulations (demes)(More)
Electron optical techniques were employed to investigate the plessite structure and composi tion of four IIICD fine octahedrites. These meteorites have a similar thermal history and differences in plessite structure can be ascribed to varying bulk Ni content and or localized differences in carbon content. Microdiffraction patterns from regions as small as(More)
The homeostat hypothesis of drug addiction states that tolerance and physical dependence may both represent adaptive processes, the body's responses to drugs that change the internal milieu. This conceptual framework inextricably links physical dependence with functional tolerance. Dependence may arise by multiple mechanisms, so that different signs, such(More)
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