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We have examined the patterns of termination of single, physiologically identified optic tract fibers in the dorsal lateral geniculate nucleus (LGNd) of the cat. The axons were impaled with a recording micropipette and characterized by their responses to light and by their conduction latencies to electrical stimulation of the optic nerve. Horseradish(More)
1. Recordings were made from single axons of 218 ganglion cells in the optic nerve of the turtle, Pseudemys scripta elegans. Responses to light stimuli were used to classify 182 of the cells into four functional groups.2. Movement-sensitive cells (113 units) responded best to moving stimuli independent of the stimulus colour or direction of motion. Their(More)
Age-dependent changes in monoaminergic systems and their relationship to senescent memory decline were investigated in 4- and 25-26-month-old, female, Fischer 344 rats. Spatial memory performance was tested on an 8-arm radial maze, and levels of norepinephrine (NE), dopamine (DA) and metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid,(More)
Because the axons of retinal ganglion cells are the sole channels carrying information from the eye, the organization of their central projections is important in visual processing. However, their detailed destinations and patterns of synaptic distribution at the level of single, functionally identified cells are not known. Most anatomical studies involve(More)
The hypothesis was tested that ON and OFF cells in the A layers of the cat's lateral geniculate nucleus (l.g.n.) form separate ON and OFF columns, and new evidence for their sublaminar distributions is presented. Evidence for columns was sought in previously published results from 184 electrode tracks oriented parallel to the layers and in new experiments,(More)
Responses to light were recorded extracellularly from single cells in the A laminae of the dorsal lateral geniculate nucleus (d.l.g.n.) in the cat. Micro-electrodes were passed through the nucleus parallel to the laminar borders allowing the depths of the cells to be measured accurately and the depth distributions of the different cell types to be(More)
A method has been devised for killing an individual neurone in the C.N.S. of the leech by injecting it with Pronase. The technique has been used to examine the role of individual sensory and motor cells involved in producing reflex movements.1. After a neurone was injected with Pronase, either in an intact animal or an isolated ganglion, its cell body lost(More)
Experiments on the lateral geniculate nucleus (LGN) of the cat based on 14C 2-deoxyglucose (2-DG) autoradiography and intraocular injections of 2-amino-4-phosphonobutyric acid (APB) provided evidence for gradients of metabolic activity in the ON and OFF pathways in layer A, but only very weakly, if at all, in layer A1. Alert and freely moving cats were(More)
Using two microelectrodes, recordings were made from pairs of like-signed cells at different depths in single layers (A or A1) of the cat's lateral geniculate nucleus (LGN). The cells were chosen to have near or overlapping receptive fields so that they could be stimulated simultaneously with a single spot or bar of light. Under these controlled conditions,(More)