D A Homonko

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OBJECTIVE There is substantial evidence that the intraarticular release of the neuropeptides substance P (SP) and/or calcitonin gene related peptide (CGRP) can contribute to the development and perpetuation of joint inflammation. However, there is a paucity of data examining whether SP and CGRP containing fibers are present in articular tissues other than(More)
Calcitonin gene-related peptide (CGRP) is present in some spinal cord motoneurons and at neuromuscular junctions in skeletal muscle. We previously reported increased numbers of CGRP-positive (CGRP+) motoneurons supplying hindlimb extensors after downhill exercise (Homonko DA and Theriault E, Inter J Sport Med 18: 1-7, 1997). The present study identifies the(More)
BACKGROUND The diagnosis of pain in the upper back, shoulder, chest, and arm is often made with considerable confusion and may be accompanied by needless expense and suffering by the patient. Despite the paucity of evidence concerning the tissues and mechanisms responsible for interscapular and atypical chest pain or "pseudo-angina," practitioners of manual(More)
In the present study, we investigated the hypotheses that 1) skeletal muscle glyconeogenesis will increase after exercise, 2) greater changes in glyconeogenesis will be observed after exercise in fast-twitch muscles than in slow-twitch muscles, and 3) glycogen repletion will reduce the rates of glyconeogenesis. Mouse soleus and extensor digitorum longus(More)
Calcitonin gene-related peptide (CGRP) is a neuroactive peptide present in some spinal cord motoneurons and at their motor endplates in skeletal muscle. Although detectable levels of CGRP change after surgical and pharmacological interruptions of neuromuscular connectivity, a clear understanding of its physiological role in the motor system is lacking. The(More)
OBJECTIVE To investigate the effect of the neuropeptide depleting agent capsaicin on neuropeptides in both synovial and nonsynovial articular tissues and on the relative degree of joint inflammation in established antigen induced arthritis (AIA). METHODS AIA was created in both knees in 3 cats. Once AIA was established, the left knee of each animal(More)
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