Désiré Bonci

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The insulin IGF-1-PI3K-Akt signaling pathway has been suggested to improve cardiac inotropism and increase Ca(2+) handling through the effects of the protein kinase Akt. However, the underlying molecular mechanisms remain largely unknown. In this study, we provide evidence for an unanticipated regulatory function of Akt controlling L-type Ca(2+) channel(More)
Figure S1. Characterization of mice lacking PDK1 expression. (A) PDK1 protein and RNA levels assessed by Western blot (top) and RT-PCR (bottom) analyses of atria and left (LV) and right (RV) ventricular cardiomyocytes from WT and KO mice. Protein and RNA loading were normalized to tu-bulin and GAPDH levels, respectively. (B) Immunofluorescence staining of(More)
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