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The current paper represents a continuation of the conference paper presented at the INES 2011 conference. It summarizes the updated results of research tasks in the field of physiological modeling and control of diseases with high public health impact carried out by the Biomedical Engineering Laboratory of the Budapest University of Technology and(More)
This paper summarizes the results of research tasks in the field of physiological modeling and control of diseases with high public health impact carried out by the Biomedical Engineering Laboratory of the Budapest University of Technology and Economics. The developed and presented optimal algorithms and strategies focus on three diseases with high public(More)
Cancer fighting treatments are expanding, and a promising type, targeted molecular therapies have a new approach. The aim of these therapies is not to eliminate the whole tumor, but to control the tumor into a given state and keep it there. Explicit knowledge of tumor growth dynamics and the effects of targeted molecular therapies is crucial in tumor(More)
Cancer is one of the most destructive and lethal illnesses of the modern civilization. In the last decades, clinical cancer research shifted toward molecular targeted therapies which have limited side effects in comparison to conventional chemotherapy and radiation therapy. Antiangiogenic therapy is one of the most promising cancer treatment methods. The(More)
Cancer diseases are one of the most lethal, incurable diseases today, thus fighting cancer is an actual and urgent problem in clinical practice. Beside classical therapies, a new approach is represented by model-based therapies, where human body works as a complex system. These therapies are called targeted molecular therapies (TMTs). TMTs are fighting(More)
Cancer represents nowadays one of the most destructive and lethal illnesses of our civilization. In the last decades, clinical cancer research shifted towards molecular targeted therapies which have limited side effects in comparison to conventional chemotherapy and radiation therapy. Antiangiogenic therapy is proved to be one of the most promising cancer(More)
The current paper represents a continuation of the conference papers presented at the INES 2011 and 2012 conferences. A brief summary of the newest results in the field of physiological modeling and control are presented focusing on high public health impact diseases: diabetes, tumor and obesity. In the case of diabetes control, preliminary model-free(More)
Model identification allows to design different control strategies for antiangiogenic cancer therapy, and create model-based treatment protocols. These model-based protocols can be more effective than the current ones, since they provide individual treatment for the patients. The aim of this paper is to investigate C38 colon adenocarcinoma growth in three(More)
BACKGROUND Bevacizumab is an exogenous inhibitor which inhibits the biological activity of human VEGF. Several studies have investigated the effectiveness of bevacizumab therapy according to different cancer types but these days there is an intense debate on its utility. We have investigated different methods to find the best tumor volume estimation since(More)
Singular configurations arise in the kinematics of revolute joint manipulators, and cause problems in solving the inverse kinematics problem. General inverse kinematics schemes are based on the Jacobian of the forward kinematics map of the manipulator, that becomes ill-conditioned in singular configurations, causing numerical instability and loss of(More)